About the Laboratory
The Laboratory of Interesting Immunology (LII) at Case Western Reserve University is located on the 10th floor of the Biomedical Research Building in close proximity to the CWRU School of Medicine and University Hospitals Cleveland Medical Center. Most LII research is focused on human immunology, Immune Dysregulation in HIV infection, the pathogenesis of persistent viral infections (such as HIV, HCV, HBV and CMV), the determinants of inflammation in cardiovascular disease, and the mechanisms of immune homeostasis in human disease. The Laboratory of Interesting Immunology has a particular interest in utilizing randomized interventions and other clinical trial designs to elucidate immunologic mechanisms of disease pathogenesis. To this end, the LII is one of three US immunology laboratories that provides immunologic monitoring of treatment trials through the NIH funded AIDS Clinical Trials Group, and is also well-supported through other funding mechanisms. See Research Themes and Faculty section for descriptions of research interests of the LII.